Fans of Michael Chabon’s The Mysteries of Pittsburgh will know there’s a movie of it coming; they may not know (spoiler, I guess, though you’ll know it fairly soon after the movie starts anyhow) that the screenplay eliminates a major character entirely. Screenwriter Rawson Marshal Thurber says:
I suppose the most glaring change is the removal, whole cloth, of Arthur Lecomte from the story. In the novel, there’s this sort of a four-pointed love rhombus — for lack of a better term — between Art, Arthur, Phlox and Cleveland. I felt strongly that in order for the film to function properly, it needed a more efficient and more cinematic engine — in short, a love triangle. So I eliminated Arthur from the narrative and folded in important elements of his character into Cleveland’s and moved from there. I think the result really gives the story the momentum needed in the medium.